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What Every Older Adult Should Know About Anemia

It’s common, usually treatable and has a big potential impact


spinner image digital illustration of red blood cells
Shuttershock

When you get routine blood test results, you probably check for certain numbers, like your cholesterol counts and blood glucose. But doctors say there’s another number that you should watch as you age: your hemoglobin count, an important marker for a condition that can have a big impact on your health.

That condition is anemia, which means having too few healthy red blood cells. Hemoglobin is the protein in those cells that carries oxygen to every tissue in your body. While anemia can cause symptoms like tiredness and weakness, the first sign may be a low hemoglobin count, often defined as under 12 grams per deciliter (g/dL) in women and under 13 g/dL in men.

Over time, studies show, older adults with even mild anemia have increased risks of falling, frailty, hospitalization and death — though it’s not clear how often anemia is a cause.

What is clear is that anemia in older adults is common and, in many cases, easily treatable, says Luigi Ferrucci, M.D., scientific director of the National Institute on Aging. “Anemia is very rare in men until the age of 65,” when it starts to become more prevalent, he says. Women are at risk during menstruating years, then get a break after menopause, until about age 65, when their rates start rising, too, he says.

A 2024 report from the Center for Disease Control and Prevention's National Center for Health Statistics found that 12.5 percent of U.S. adults ages 60 and older have anemia, compared with 9 percent of adults ages 20 to 59. 

If you’re anemic, it’s important to try to find out why, experts say. Too often, anemia in older adults “is ignored, with symptoms normalized,” says Michael Auerbach, M.D., a hematologist-oncologist and clinical professor of medicine at the Georgetown University School of Medicine in Washington, D.C. In addition to tiredness and weakness, those symptoms can include shortness of breath, pale or yellowish skin, dizziness, irregular heartbeat, cold hands and feet, and headaches.

Here’s what you need to know about the five most common causes of anemia — plus how to up your iron intake.

1. Iron deficiency

If your body doesn’t have enough iron, you can’t make enough hemoglobin, leading to anemia. Low iron is the most common treatable cause of anemia in older adults, says Andrew Artz, M.D, a hematologist-oncologist at the cancer treatment and research center at City of Hope in Duarte, California. So, it’s the first thing your doctor should check if your hemoglobin is low, or if you have telltale signs of low iron — such as a sudden desire to chew ice, he says. Simple blood tests can show how much iron is in your bloodstream and stored in your body, he says.

But Artz says the testing shouldn’t stop there. When older adults in the United States have an iron deficiency, he says, it’s unlikely that poor diet is a major cause. Sometimes, he says, it’s because they have trouble absorbing iron, which can happen after stomach surgery or with conditions like celiac disease.

But often, he says, it means they’re losing blood, most often from the digestive tract. Causes can include stomach ulcers, cancers, recent surgery, taking aspirin or even having a lot of blood tests, he says. If the cause isn’t obvious, your doctors might suggest stool blood tests or procedures to look at your lower and upper digestive tract, such as colonoscopy and upper endoscopy.

Treatment means finding and addressing the cause and replacing the iron with pills or intravenous treatments. (See sidebar.)

2. Chronic kidney disease

Our kidneys produce a hormone called erythropoietin (EPO) that is essential to red blood cell production. When you have chronic kidney disease, your kidneys don’t produce enough EPO. In severe cases, this kind of anemia is treated with injections of synthetic EPO, Artz says.

3. Inflammation linked to chronic disease

Many common diseases — including autoimmune diseases like rheumatoid arthritis as well as diabetes, heart failure, chronic infections and cancer — cause inflammation. Such inflammation can lead to anemia by decreasing EPO production, Artz says. It also can trigger the body to reduce iron in the blood — something that probably developed in our ancestors as a natural defense against infection, not long-lasting inflammation, Ferrucci says: “Now, instead of being protective, it is problematic.”

Treating the underlying cause is usually the best approach for this kind of anemia, Artz says: “If you treat someone who has rheumatoid arthritis and they feel better, a lot of times the anemia gets better, too.”

4. Blood cancers and bone marrow disorders

Blood cancers make up a “small sliver” of anemia cases and are usually associated with severe anemia and other blood test abnormalities, Artz says. Cancers that can directly cause anemia include leukemias, lymphomas and multiple myeloma, according to the American Cancer Society. Other disorders that affect bone marrow, such as myelodysplastic syndromes (MDS), can also lead to anemia, as can cancer therapies such as chemotherapy and radiation, the society says.

If your anemia is mild, many doctors would consider your risk of these conditions too low to test for them with a bone marrow biopsy, Ferrucci says.

5. Unexplained anemia

If you don’t have low iron, kidney disease or an inflammatory condition, and testing hasn’t turned up a less common cause, such as a thyroid disorder or a shortage of folate or vitamin B12, you have “unexplained anemia of aging,” Ferrucci says. That would put you in a lot of company: Studies suggest roughly a third of anemia diagnoses after age 65 fall into this basket. About 90 percent of them are mild cases.

Doctors know mild anemia is associated with poor health in old age, but don’t know if unexplained anemia is mostly a cause or an effect of declining health, Ferrucci says. “Correcting anemia may not solve the problem because the underlying condition is still there,” he says. He and other researchers are working on finding those underlying causes, he says.

Right now, there’s no specific treatment for unexplained anemia of aging, Artz says. If you have it, he says, your doctors may just ask you to come for blood tests every six months to two years. If hemoglobin levels stay fairly stable, that’s a good sign, he says. He notes, though, that hemoglobin levels tend to gradually decline with age, even in healthy, nonanemic people.

There is a bright side when a thorough investigation turns up nothing, he adds: “When we don’t find something serious, it’s reassuring.”

Getting enough iron

Most older Americans get enough iron in their diets, according to the National Institutes of Health (NIH). Sources include:

  • Meat
  • Seafood
  • Nuts
  • Beans
  • Vegetables
  • Fortified breads, cereals and other grains

But if you have iron deficiency anemia, caused by bleeding, poor absorption or other causes, you need more. That usually means taking iron supplements or getting an intravenous infusion of iron.

Infusions, which are more expensive, can be appropriate for people who have trouble absorbing iron, or have inflammatory bowel disease, chronic kidney disease or ongoing blood loss, according to guidelines from the American Gastroenterological Association. Michael Auerbach, M.D., a hematologist-oncologist in Washington, D.C., says he uses IV treatments in all his older patients, to spare them side effects from iron pills, such as constipation. One treatment, he says, is usually enough.

If you do take iron pills, he says, you absorb at least as much iron, with fewer side effects, if you take them every other day or twice a week instead of daily. He also suggests taking the pills with orange juice, since vitamin C may help iron absorption.

Other tips for taking iron pills, from the NIH:

  • Iron is best absorbed on an empty stomach, but you might need a little food to ward off side effects like nausea.
  • Avoid taking iron within two hours of having milk, calcium supplements or antacids.
  • Don’t take iron with coffee, tea or high-fiber foods, which might limit absorption.
  • Check with your doctor about how iron might interact with your other medicines.
  • Keep iron pills out of reach of children. Contact poison control if a child swallows a pill.

Editor's note: This story, first published April 26, 2024, has been updated to include new information. 

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