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Gen Xers Face Higher Cancer Risks Than Boomers 

Younger generations are getting hit harder than their predecessors by 17 types of cancer  


spinner image illustration of cancer cells
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Cancer trends in the U.S. are shifting, and accumulating research paints a concerning picture for America’s “middle child generation” and those that follow. 

Members of Generation X — adults born between 1965 and 1980 — are more likely to be diagnosed with cancer than the generations that came before them, researchers from the National Cancer Institute found. Published in June in the journal JAMA Network Open, the study looked at data from 3.8 million individuals in the U.S. diagnosed with invasive cancer from 1992 to 2018. Using modeling, the researchers found that as Gen X adults hit 60, they will be more likely to get cancer than baby boomers were at age 60.

A study published July 31 in The Lancet Public Health found that Gen Xers and millennials have a higher risk of developing 17 of 34 types of cancers compared with older generations, including nine cancers that had been declining in older adults.

17 Cancers on the Rise in Younger Generations   

According to a study published in The Lancet Public Health, researchers found that compared with older generations, Generation X and millennials in the U.S. have a higher risk of developing these cancers:   

  • Colorectum
  • Uterine corpus
  • Gallbladder
  • Kidney and renal pelvis
  • Pancreas
  • Myeloma
  • Noncardia gastric, a type of stomach cancer
  • Leukemia
  • Testis
  • Cardia gastric, a type of stomach cancer
  • Small intestine
  • Estrogen receptor-positive breast
  • Ovary
  • Liver (in women)
  • Non-HPV-associated oral and pharynx (in women)
  • Anus (in men)
  • Kaposi sarcoma, a type of blood cancer (in men)

Strikingly, the researchers, led by a team from the American Cancer Society, found that adults born around 1990 are two to three times more likely to develop pancreatic, kidney, liver (in women) and small intestinal cancers than adults born around 1955. Younger adults are also seeing an increase in mortality for five different types of cancer, including liver (in women), uterine, gallbladder, testicular and colorectal cancers, the study found.

“These findings add to growing evidence of increased cancer risk in post-baby boomer generations,” Hyuna Sung, coauthor of the Lancet study and a senior principal scientist of surveillance and health equity science at the American Cancer Society, said in a statement.

What’s driving the cancer increase?

Even though we’re recognizing cancer trends associated with birth years, “we don’t yet have a clear explanation for why these rates are rising,” Sung says.

That’s not to say there aren’t clues, and many cancer experts point to rising obesity rates and environmental exposures as two likely possibilities.

1. Rising obesity rates. Underlying genetics can contribute to cancer risk, explains Sanjay Shete, a genetic epidemiologist at the University of Texas MD Anderson Cancer Center in Houston. “But I don’t think [that’s what] has changed” in recent decades, he says.

“What has definitely changed is our lack of physical activity, the increased obesity rates and also availability of fast foods that were not so much frequently available to the baby boomers and the silent generation. And I think that’s probably the primary driver of why we’re observing increased cancer incidence in the younger population.” 

Obesity rates in the U.S. have soared in recent decades, rising from around 13 percent in 1980 to 42 percent by 2020. Less than a quarter of U.S. adults get the recommended amount of physical activity, data from the Centers for Disease Control and Prevention (CDC) shows.

What does this have to do with cancer? According to the National Cancer Institute, there is “strong evidence” that higher levels of physical activity are linked to lower cancer risks. And the CDC has linked 13 types of cancer to obesity:

  • Breast cancer (in women)
  • Colon and rectal cancer
  • Endometrial cancer (also called uterine cancer)
  • Esophagus cancer
  • Gallbladder cancer
  • Stomach cancer
  • Kidney cancer
  • Liver cancer
  • Ovarian cancer
  • Pancreatic cancer
  • Thyroid cancer
  • Meningioma (a type of brain cancer)
  • Multiple myeloma

Being overweight may increase the risk for several others, including non-Hodgkin lymphoma; mouth, throat and voice box cancer; and aggressive forms of prostate cancer, the American Cancer Society says.

“When you look at this list of obesity-related cancers, you will see a strong overlap” with the cancers that are increasing among Gen Xers, says Urvi A. Shah, M.D., a hematologist-oncologist at Memorial Sloan Kettering Cancer Center in New York.

Shah, a specialist in multiple myeloma, says the bone marrow cancer has been thought of as a disease that primarily affects the older population. “That’s still the majority of cases,” she says, “but we are starting to see younger patients in clinic too, which is surprising to us and not really expected.”

2. Sleep, environment and the microbiome. Obesity isn’t the only explanation. Plenty of adults who are diagnosed with cancer are physically active and not overweight, indicating other factors are at play.

Scientists suggest poor sleep and exposure to chemicals and pollutants in the environment may contribute to increasing cancer rates among younger adults. The Lancet authors note “the potential involvement of an altered microbiome, given substantial changes in dietary patterns and antibiotics use in particular over the past few decades.”  

The microbiome, sometimes called the gut, refers to the trillions of bacteria, fungi and other organisms living in the large intestine. Accumulating research finds that this community of bugs plays a critical role in the body’s overall health — so keeping it happy is key.

A high-fiber diet is one way to do that, researchers say. Some studies estimate that as many as 95 percent of Americans don’t get enough fiber in their diet, which is 25 to 30 grams a day from food sources, not supplements.

“The microbiome directly feeds on fibers. So if you don’t feed it enough fiber, you don’t have healthy microbiome,” Shah explains. Adding 1 cup of beans, which has 15 grams of fiber, to your daily diet can help increase your intake, she says. “We should not minimize the effect or the importance of fiber.”

The gut can also be altered by environmental exposures and pollutants, as well as alcohol, tobacco, antibiotics, even stress.  

Lowering your cancer risks

Ahmedin Jemal, a senior vice president at the American Cancer Society and a coauthor of the Lancet study, says the data highlights a “critical need” to both identify and address the factors that fuel the trends in Gen X and millennial populations. 

“Without effective population-level interventions, and as the elevated risk in younger generations is carried over as individuals age, an overall increase in cancer burden could occur in the future, halting or reversing decades of progress against the disease,” he said in a statement.

While research into the causes behind increasing cancer rates continues, doctors and scientists say there are several things individuals in their 40s and 50s can do to help lower their risks.

  • Eat more plants. Don’t just increase the amount you eat, increase the variety — aim for about 30 different types of plants each week, Shah says, referring to studies that show a diversified diet has been shown to improve the health of the microbiome. That number may seem daunting, but if you have berries with your breakfast, legumes with your lunch, nuts for a snack and a mix of vegetables with dinner, you’re well on your way. “If you just make a stew with multiple kinds of beans or a curry with many veggies, you’re already getting five or 10 in that one meal,” Shah says. Incorporating fermented foods — yogurt, kimchi and sauerkraut, for example — can also help your gut, Shah adds.
  • Cut back on ultraprocessed foods. The majority of the American diet (more than 60 percent) consists of ultraprocessed foods — your packaged snacks, frozen dinners and fast-food favorites. Studies have linked a diet high in these foods, stripped of fiber and other nutrients, with increased risk of some cancers. Processed meats, in particular, are considered carcinogens, or substances that can increase cancer risk, which is why cancer experts recommend restricting them as much as possible.
  • Limit alcohol. More research is coming out about the health impacts of alcohol. According to the CDC, drinking alcohol raises your risk for several kinds of cancer, including mouth and throat, esophagus, colon and rectum, liver and breast (in women). Drinking alcohol has long been viewed as a socially acceptable activity, Shete says, “but I think the more data we’re getting, we’re realizing that … alcohol consumption should go down substantially.”
  • Stay physically active. Staying active as you age lowers your risk for developing at least eight types of cancer, according to the CDC, including breast, colon and kidney cancer. How so? Exercise can help prevent high levels of insulin and inflammation, which are associated with cancer development, explains the National Cancer Institute. Staying active can also improve the immune system and digestive system, both of which have been linked to lower cancer risks.

Quitting smoking, protecting yourself from the sun and getting vaccines that protect against viral infections known to cause cancer also can help lower risks.

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